The HHS Overdose Prevention Strategy has been designed to increase access to the full range of care and services for individuals who use substances that cause overdose, and their families. This tool which supports the new HHS prevention strategy focuses on the multiple substances involved in overdose and the diverse treatment approaches for substance use disorder. The new strategy prioritizes four key target areas—primary prevention, harm reduction, evidence-based treatment, and recovery support - principles of maximizing health equity for underserved populations, using best available data and evidence to inform policy and actions, integrating substance use disorder services into other types of health care and social services, and reducing stigma.